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Promethazine / codeine: Basics, Side Effects & Reviews - GoodRx Promethazine / codeine is a combination of two medications: promethazine and codeine. Promethazine is a phenothiazine medication that blocks the signals in your brain and body causing you to experience cold and allergy symptoms like a runny nose and sneezing. Codeine is an opioid medication that works in your brain to lessen your urge to cough.

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